Kitty Norville, a closeted werewolf hosts a popular Denver radio program called The Midnight Hour. During her show, Kitty takes phone calls from listeners (not all of whom are human) while trying to maintain her secret identity.
Unfortunately, the local vampire crime family wants her show canceled and has hired someone to kill her. In fact, it's during the course of Kitty's dramatic on-air conversation with her would-be assassin that she reveals to listeners that she is, indeed, a werewolf. Eventually, local police enlist her to help track down a serial killer who exhibits werewolflike tendencies.